Use numbers to indicate the order of steps in the pyruvate dehydrogenase complex: 1. _______Decarboxylation of pyruvate to an aldehyde 2. __

Question

Use numbers to indicate the order of steps in the pyruvate dehydrogenase complex: 1. _______Decarboxylation of pyruvate to an aldehyde 2. _______Formation of acetyl CoA 3. _______Regeneration of the oxidized FAD cofactor 4. _______Oxidation of aldehyde to a carboxylic acid 5. _______Reoxidation of the lipoamide cofactor

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Abigail 3 months 2022-02-18T05:40:30+00:00 1 Answer 0 views 0

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    2022-02-18T05:41:46+00:00

    Answer:

    1-4-2-3-5

    Explanation:

    The PDHC is made up of multiple copies of 3 different enzymes: pyruvate dehydrogenase (PDH, E1: 20-30 copies), dihydrolipoamide S-acetyltransferase (DLAT, E2: 60 copies) and dehydrogenase dihydrolipoamide, (DLD, E3: 6 copies). The complex also requires five different coenzymes: CoA, NAD +, FAD +, lipoic, and thiamine pyrophosphate (TPP). Three of the complex coenzymes are closely linked to the complex enzymes (TPP, lipoic acid, and FAD +) and two are used as carriers of the products of PDHC activity (CoA and NAD +). The pathway for oxidation of PDH from pyruvate to acetyl-CoA is a diagram below.

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45:5+15-5:5+20+17*12-15 = ? ( )